I have no idea whether you are talking about XBMC, MediaMonkey, iTunes, Windows Media Centre, JRiver Media Centre, or Mediaportal or some other program but no, in most cases it does not matter where your music is located. The way that VoxCommando talks to each of these program is different, but in most cases VC is only requesting the music by an ID or by specifying the name of the song, artist, album etc. and VC does not care where the music is located. Of course your media program needs to know where the music is located.