Yes, their software works only with MCE, but the remote works great with VoxCommando. I am working in cooperation with Amulet as well to see if I can use some custom code for VoxCommando to take advantage of information about the position of the remote. When you put the remote down so that it is horizontal the microphone turns off. When you lift it to your mouth, it turns on and a red light lights up to let you know that it is ready. I am hoping to also detect when this happens so that we can (optionally) lower the volume of our music or video while the microphone is on.
I have done tests with relatively loud music, and even without lowering the volume it works quite well because you hold the mic relatively close to your mouth, and after your command you just put it back down and it stops listening.
The range on this thing is also very good. Up to 90 feet in open air. I was able to go two floors up and to the other end of my house and was just starting to lose the connection at the far end of the house.
I believe it is compatible with any MCE IR receiver which means that all buttons can be reprogrammed using eventGhost. It also has a learning function so certain buttons can be taught to control the volume on your TV etc. In theory with the correct setup you could eliminate the need for all your other remotes.
The Amulet software seems to be very nicely tied in to Windows Media Center. They have added a lot of stuff to MCE to improve the experience, and setup is extremely easy but I have not really tested that much because I am not really interested in using Media Center myself.